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In diabetes, molecular-level dysregulation of this finely tuned process, which causes chronic inflammation, inhibition of angiogenesis, impaired collagen synthesis, and defective tissue remodelling

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It is not, however, a human long-term safety clearance

Notably, some of these Cl transporters in -cells can be directly targeted by thiazide and loop diuretics (Di Fulvio and Aguilar-Bryan, 2019)